Efektivitas Ekstrak Bunga Telang (Clitoria Ternatea L.) untuk Menurunkan Kadar Gula Darah: Literature Review

Deskrisman Stefan Mendrofa, Angenia Itoniat Zega, Evi Karota

Abstract


Hiperglikemia merupakan kondisi peningkatan glukosa darah melebihi batas normal dan menjadi masalah penyakit diabetes yang memerlukan penatalaksanaan yang cepat dan tepat. Bunga telang menjadi salah satu terapi alternatif untuk menurunkan glukosa darah penderita diabetes. Tujuan penelitian: Penelitian ini bertujuan untuk mencari data tentang efektivitas ekstrak bunga telang (Clitoria ternatea L.) yang merupakan antidiabetes untuk menurunkan KGD penderita diabetes sebagai terapi pendamping berbahan herbal Metode: Penelusuran literatur review dengan pencarian artikel ilmiah menggunakan tiga database elektronik, yaitu Google Scholar, Science Direct, dan Proquest. Artikel yang terseleksi sebagai sumber literatur berdasarkan beberapa kriteria inklusi, publikasi artikel lima tahun terakhir (Januari 2019–Maret 2024), dan membahas efektivitas bunga telang sebagai antidiabetes yang dipublikasikan pada jurnal terakreditasi nasional dan jurnal bereputasi internasional. Analisis data dilakukan dengan ekstraksi research evidence efikasi klinis efektivitas bunga telang terhadap penurunan kadar glukosa darah. Hasil: Delapan artikel menunjukkan hasil uji ekstrak bunga telang berpengaruh terhadap penurunan kadar glukosa darah melalui peningkatkan produksi dan sekresi insulin sehingga dapat menurunkan glukosa darah. Hasil uji juga meningkatkan serum CAT, SOD, dan bermanfaat sebagai antioksidan, antiinflamasi, serta menurunkan sel nekrotik. Diskusi: Bunga telang dapat digunakan sebagai terapi alternatif antidiabetes yang memiliki potensi produksi dan sekresi insulin untuk menurunkan KGD penderita diabetes serta mencegah meluasnya kerusakan fungsi pankreas. Namun demikian, studi ini masih terbatas pada percobaan hewan. Kesimpulan: Ekstrak bunga telang efektif sebagai antidiabetes untuk menurunkan kadar glukosa darah penderita diabetes. Diperlukan penelitian lanjutan untuk mengevaluasi efek terapi ekstrak bunga telang terhadap penderita diabetes di masyarakat.

Kata Kunci: antidiabetes, ekstrak bunga telang, kadar glukosa darah

 

EFFECTIVENESS OF BUTTERFLY PEA FLOWER EXTRACT (CLITORIA TERNATEA L.) IN LOWERING BLOOD GLUCOSE LEVELS: A LITERATURE REVIEW

 

ABSTRACT 

Hyperglycemia, characterized by elevated blood glucose levels beyond normal limits, is a condition requiring rapid and appropriate management, especially for diabetes patients. Butterfly pea flower has emerged as an alternative therapy to help lower blood glucose in diabetes patients. Objective: To review data on the effectiveness of butterfly pea flower extract (Clitoria Ternatea L.), an herbal antidiabetic agent, in lowering blood glucose levels (BGL) among diabetes patients as a complementary therapy. Methods: A literature review was conducted by searching scientific articles across three electronic databases: Google Scholar, Science Direct, and Proquest. Articles selected as literature sources met the inclusion criteria, which included publication within the past five years (January 2019–March 2024) and discussions on the effectiveness of butterfly pea flower as an antidiabetic, published in nationally accredited and internationally reputable journals. Data analysis involved extracting research evidence on the clinical efficacy of butterfly pea flower in reducing blood glucose levels. Results: Eight studies indicated that butterfly pea flower extract significantly reduced blood glucose levels by enhancing insulin production and secretion, leading to decreased blood glucose levels. The trials also showed an increase in serum CAT and SOD levels, with antioxidant, anti-inflammatory benefits, and reduced necrotic cells. Discussion: Butterfly pea flower can serve as an alternative antidiabetic therapy, with potential to stimulate insulin production and secretion to lower BGL in diabetes patients and to prevent extensive pancreatic damage; however, current studies are limited to animal trials. Conclusion: Butterfly pea flower extract is effective as an antidiabetic agent in lowering blood glucose levels in diabetes patients. Further research is needed to evaluate the therapeutic effects of butterfly pea flower extract in the diabetic population.

Keywords: antidiabetic, butterfly pea flower extract, blood glucose levels


References


Bergman, M., Manco, M., Satman, I., Chan, J., Schmidt, M.I., Sesti, G., Fiorentino, T.V., Abdul-Ghani, M., Jagannathan, R., Aravindakshan, P.K.T. and Gabriel, R. (2024). International Diabetes Federation Position Statement on the 1-hour post-load plasma glucose for the diagnosis of intermediate hyperglycaemia and type 2 diabetes. Diabetes research and clinical practice, 209, 111589.

Cahyaningsih E., Yuda, P. E. S. K., Santoso, P. (2019). Phytochemical Screening and Antioxidant Activity Test of Ethanol Extract of Telang Flowers (Clitoria Ternatea L.) Using Uv-Vis Spectrophotometry Method. JINTO, 5(1): 51–7.

Chayaratanasin, P., Adisakwattana, S., & Thilavech, T. (2021). Protective role of Clitoria Ternatea L. flower extract on methylglyoxal-induced protein glycation and oxidative damage to DNA. BMC Complementary Medicine and Therapies, 21(1), 1–11. https://doi.org/10.1186/s12906-021-03255-9.

Dewi, I., Chodidjah, C., & Atina, H. (2023). Evaluation of Clitoria ternatea L. Flower Extract in Preventing Complications of Diabetes Mellitus. Tropical Journal of Natural Product Research, 7(10), 4908-4911.

Ergasheva, G. T. (2022). In Patients with Diabetes Improving Rehabilitation Criteria. Education and Development. online Science Journal of Analysis, 2(12), 335-337.

Fredy, E. S., Yusuf, S., & Syahrul, S. (2023). Model edukasi pelaksanaan discharge planning pada pasien dengan stoma (Ostomate): A systematic review. Jurnal Persatuan Perawat Nasional Indonesia, 8(3), 139-155.

Gunawan, O., Putranto, R. P. A., Subandono, J., & Budiastuti, V. I. (2023). The Effect of Butterfly Pea Extract on Blood Glucose Levels in White Rats with Metabolic Syndrome Model. Smart Medical Journal, 6(1), 14. doi.org/10.13057/smj.v6i1.67934.

Indriyati, Y. F., & Dewi, D. N. (2022). Potensi Bunga Telang (Clitoria Ternatea) Sebagai Antidiabetes. Generics: Journal of Research in Pharmacy, 2(1), 1–8.

JBI. (2023). JBI Critical Appraisal Tool: JBI Checklist for Quasi-experimental Studies. Retrieved from https://jbi.global/critical-appraisal-tools

Kementerian Kesehatan Republik Indonesia. (2020). Keputusan Menteri Kesehatan Republik Indonesia Nomor HK.01.07/MENKES/603/2020/ Tentang Pedoman Nasional Pelayanan Kedokteran Tata Laksana Diabetes Melitus Tipe 2 Dewasa. Retrieved from https://yankes.kemkes.go.id/unduhan/fileunduhan_1610340996_61925.pdf

Kementerian Kesehatan Republik Indonesia. (2019). Laporan Riskesdas 2018 Nasional. Lembaga Penerbit Balitbangkes (pp. xliii–628). Jakarta: Lembaga Penerbit Badan Penelitian dan Pengembangan Kesehatan.

Kusuma, E. W., Anggraini, D. I., & Semartini, A. (2024). Si Cantik Bunga Telang (Clitoria Ternatae L.) Untuk Mengatasi Diabetes Mellitus. SWAGATI: Journal of Community Service, 1(3), 181–186.

https://doi.org/10.24076/swagati.2023v1i3.1220.

Marpaung, A. M. (2020). Tinjauan manfaat bunga telang (Clitoria Ternatea L.) bagi kesehatan manusia. Journal of Functional Food and Nutraceutical, 1(2), 63-85.

Mobasher, M. A., Baioumy, S. A., Alazzouni, A. S., Khayyat, A. I. A., Awad, N. S., Abdel-Hakeem, M. A., & Al-Sowayan, N. S. (2023). Clitoria ternatea extract-loaded chitosan nanoparticles ameliorate diabetes and oxidative stress in diabetic rats. Indian Journal of Biochemistry and Biophysics, 60(7), 501–515. doi.org/10.56042/ijbb.v60i7.4140.

Pangondian, A., Rambe, R., Umaya, C., Athaillah, A., & Jambak, K. (2023). Potensi Ekstrak Bunga Telang (Clitorea Ternatea L.) Terhadap Antidiabetes Pada Mencit Putih Jantan (Mus musculus). Forte Journal, 3(2), 150–157. https://doi.org/10.51771/fj.v3i2.630

Putri, T. F., Wasita, B., & Indarto, D. (2023). Administrations of Butterfly Pea Flower (Clitoria Ternatea L) Extract reduce oxidative stress and increase body weight of male wistar rats with diabetes. Amerta Nutrition, 7(3), 400-405. doi.org/10.20473/amnt.v7i3.2023.400-405

Rosni, R., Lister, I. N. E., Fachrial, E., Ginting, S. F., Widowati, W., & Wahyuni, C. D. (2021). Potential of Gnetum gnemon L. Seed Extract Against Insulin Levels and PDX-1 Expression in Diabetes Mellitus Rats Model. In 2021 IEEE International Conference on Health, Instrumentation & Measurement, and Natural Sciences (InHeNce) (pp. 1-5). IEEE.

Sasmana, I. G. A. P., Surudarma, I. W., Wiryanthini, I. A. D., & Sutadarma, I. W. G. (2024). Antihyperglycemic and pancreas protective effects of butterfly pea flower (Clitoria Ternatea) aqueous extract in hyperglycemic mice. Intisari Sains Medis, 15(1), 86–91. Doi.org/10.15562/ism.v15i1.1906

Simangunsong, M. V., Febriani, Y., Saputri, M., Arisa, D., & Afifah, G. Z. (2023). Effectiveness of Butterfly Pea Ethanol Extract on Decreasing Blood Glucose Levels of Male Mice. Jambura Journal of Health Science and Research, 5(2), 707-721. https://ejurnal.ung.ac.id/index.php/jjhsr/index

Numsang, P., Oumtanee, A., Kurat, S., Sananok, R., Kraichan, S., Sarapoke, P. (2023). Failure to control blood sugar experiences of persons with type 2 diabetes mellitus. International Journal of Nursing Sciences, 10, 527-532.

doi.org/10.1016/j.ijnss.2023.09.004

Tokhirovna, E. G. (2023). Study of clinical characteristics of patients with type 2 diabetes mellitus in middle and old age. Journal of Science in Medicine and Life, 1(4), 16-19.

Tod, D., Booth, A., & Smith, B. (2022). Critical appraisal. International Review of Sport and Exercise Psychology, 15(1), 52-72. https://doi.org/10.1080/1750984X.2021.1952471

Widowati, W., Darsono, L., Lucianus, J., Setiabudi, E., Susang Obeng, S., Stefani, S., Wahyudianingsih, R., Reynaldo Tandibua, K., Gunawan, R., Riski Wijayanti, C., Novianto, A., Sari Widya Kusuma, H., & Rizal, R. (2023). Butterfly pea flower (Clitoria Ternatea L.) extract displayed antidiabetic effects through antioxidant, anti-inflammatory, lower hepatic GSK-3β, and pancreatic glycogen on Diabetes Mellitus and dyslipidemia rat. Journal of King Saud University - Science, 35(4), 102579. doi.org/10.1016/j.jksus.2023.102579




DOI: http://dx.doi.org/10.32419/jppni.v9i1.586

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